With Windows 7 being a slightly modified version of Vista there is no reason why it should not work. I run Vista x64 and I don't have any issues. Yes, there are some things that will be different but a bit of patience and being willing to ask for help on the forums will generally get you through most problems that arise.
Mysql setup seems to be the worst part of the initial setup because it usually does fail but that also happens under XP. A simple reconfiguration of the settings fixes the setup gliche. That problem arises from the program trying to start a service that is already runnning and that is not possible.
And no compatibility mode is not necessary. The need for compatibility mode under Vista is lack of updating by the user. At Windows 7 launch it will be equal to Vista SP3 so compatibility issues should be non existant.
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