Are you on the newer "Strawberry" Perl installation? I don't specifically remember a "locked" message but I do remember having issues when starting things up a few months ago. It turns out my install was no longer compatible with the old Perl and I had to move to Strawberry.
I ended up doing a completely fresh install, because my custom changes are pretty easy to re-implement, but you may have to do some elaborate backing up if you've made a lot of changes.
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