You can change the stats on weapons and such in the DB as well as Spells (in the spells file). As for weapons that would only affect players that equip those weapons so it should not affect NPC in anyway. Spells; however, are a different story. If you change the spell damage in the Spells file then anyone that cast that spell including NPCs will be affected.
You can also lower NPC stats to make them more manageable. The NPC stats are controlled completely by the DB in the npc_types table. Poking around in there should give you some ideas of how you could nerf the NPC themselves to make them easier to kill by an equivalent PC.
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