Best practice to initialize qglobals?

[revloc02c]

Here's one way to initialize a qglobal:

sub EVENT_SPAWN {
	quest::set_proximity($x - 50, $x + 50, $y - 50, $y + 50);
}

sub EVENT_ENTER {
	if(!defined $qglobals{some_nice_qglobal}) {
		quest::setglobal("some_nice_qglobal", 0, 5, "F");
	}
}

Does setting a proximity utilize more resources? than say just checking for the qglobal whether the PC initiates with the NPC by saying something or giving an item, like so:

sub EVENT_SAY {
	if(!defined $qglobals{some_nice_qglobal}) {
		quest::setglobal("some_nice_qglobal", 0, 5, "F");
	}

	# ...other EVENT_SAY code...
}

sub EVENT_ITEM {
	if(!defined $qglobals{some_nice_qglobal}) {
		quest::setglobal("some_nice_qglobal", 0, 5, "F");
	}

	# ...other EVENT_ITEM code...
}

...or is there another better way altogether?

Or does it even matter?